Autoimmune diseases and lupus

GLENN ELLIS | 7/17/2018, 1:45 p.m.
More and more, we are all hearing about friends, family, and even celebrities who are “victims” of autoimmune diseases – ...
Local individuals with lupus, family members and other support groups participate in a lupus awareness walk. Lupus Foundation of America

Strategies for Well-Being

More and more, we are all hearing about friends, family, and even celebrities who are “victims” of autoimmune diseases – especially Lupus.

The ultimate autoimmune disease – systemic lupus erythematosus – is more common in Blacks than non-Black persons but many other autoimmune diseases do not show any racial preferences.

Lupus is a systemic autoimmune disease driven by inflammation in which the immune system indiscriminately attacks “self-tissues” throughout the body.

Parts of the body frequently affected by lupus include the skin, kidneys, heart and vascular system, nervous system, connective tissues, musculoskeletal system, and other organ systems.

Your immune system is the network of cells and tissues throughout your body that work together to defend you from invasion and infection.

The more primitive innate – or inborn – immune system activates white blood cells to destroy invaders. The innate system alerts the body to danger when it senses the presence of parts that are often found in many viruses or bacteria. The acquired – or adaptive – immune system develops as a person grows. It “remembers” different invaders so that it can fight them better if they come back. When the immune system is working properly, foreign invaders – antigens – provoke the body to produce proteins called antibodies and specific types of white blood cells that help in defense. The antibodies attach to the invaders so that they can be recognized and destroyed.

Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. In other words, the body actually attacks its own cells.

Normally the immune system’s white blood cells help protect the body from harmful substances, called antigens. Examples of antigens include bacteria, viruses, toxins, cancer cells, and blood or tissues from another person or species. The immune system produces antibodies that destroy these harmful substances.

What causes the immune system to no longer tell the difference between healthy body tissues and antigens is unknown. One theory is that some microorganisms – such as bacteria or viruses – or drugs may trigger some of these changes, especially in people who have genes that make them more likely to get autoimmune disorders.

These diseases tend to run in families. Women – particularly African American, Hispanic American and Native American women – have a higher risk for some autoimmune diseases.

There are more than 80 types of autoimmune diseases, and some have similar symptoms. This makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. Getting diagnosed can be frustrating and stressful. In many people, the first symptoms are being tired, muscle aches and low fever.

The diseases may also have flare-ups, when they get worse, and remissions, when they all but disappear. The diseases do not usually go away, but symptoms can be treated.

Autoimmune diseases can affect almost any part of the body, including the heart, brain, nerves, muscles, skin, eyes, joints, lungs, kidneys, glands, the digestive tract and blood vessels.